Gem of Efficacious Toxin Legendary Gem Diablo 3

Last Updated on July 21, 2022 by Sam

A Legendary Gem in Diablo III is the Gem of Efficacious Toxin. It only drops from Greater Rift Guardians and may be socketed into Amulets and Rings.

This gem renders any opponent that is assaulted poisonous over time, regardless of the attack’s, skill’s, or spell’s Proc Coefficient. Further assaults renew this effect, but it does not stack. Upgrades result in more damage being done overall (and the damage per second).

This gem is beneficial to classes who concentrate on elements other than Poison since at level 25, it also boosts all damage that the poisoned victim suffers from all sources (including other players). The penalty does accumulate across different players (see example video). Additionally, enemies that are afflicted take less damage from all attacks, even stacking strikes from several players.

The poison will be applied by the player character or any harmful attacks performed by their pets. It will only be used on casts, however. DoT effects won’t thus renew the poisoning.

Also take notice that although the Raiment of the Jade Harvester Set bonus does not apply the new poisoning, it does deplete the Gem of Efficacious Toxin effect. The damage boost is considerably less than it would be since this gem does not benefit from Creeping Death and Quetzalcoatl.

The Witch Doctor and Necromancer are the only classes that may be able to improve this gem with elemental damage skill boosts since it utilises Poison damage.

Gem of Efficacious Toxin Legendary Gem Diablo 3

Gem Properties

Gem of Efficacious Toxin

  • Poison all enemies hit for 1000% weapon damage over 10 seconds.
  • Upgrade rank grants: +20% weapon damage over 10 seconds.

Rank 25 unlocks:

  • All enemies you poison take 10% increased damage from all sources.

Gem of Efficacious Toxin Mechanics

This Gem applies a Poison Damage over Time effect for 2000% weapon damage over 10 seconds onto enemies when attacking them. You can level this Gem all the way up to rank 150. Every upgrade will increase the Poison damage by another 50% weapon damage up to a maximum of 9,500% total.

The rank 25 secondary bonus is the reason this Gem is played in every Support build in the game: All enemies you poison take 10% additive increased damage from all sources (including your party members) and also deal 10% less damage. Only the additive damage increase effects stacks with multiple Gem of Efficacious Toxin in the party!

 ToxinGem of Efficacious Best Use

The support Gem: Used in most support builds for the awesome party benefits. Has not been used in an offensive way in ages as the base DoT damage is way too low. Leveling this gem past rank 25 is not recommended because DoT damage is completely irrelevant.

ToxinGem of Efficacious Stats at Higher Ranks

Rank weapon damage over 10 seconds
Rank 1 1000%
Rank 2 1020%
Rank 3 1040%
Rank 4 1060%
Rank 5 1080%
Rank 10 1180%
Rank 15 1280%
Rank 20 1380%
Rank 25 1480%
Rank 30 1580%
Rank 35 1680%
Rank 40 1780%
Rank 45 1880%
Rank 50 1980%

Legendary Gem in Diablo 3

Legendary Gem Creation:

If you need extra Legendary Gems to level up, you can make the Rift Guardian in any Greater Rift drop a new Rank 0 Gem by removing all the Legendary Gems with the same name from your Equipment, Inventory and Stash.

The safest way to do that is to put them into the Inventory of different character.

List Of All 23 Legendary Gems:

Bane of the Stricken Bane of the Trapped Boon of the Hoarder Boyarsky’s Chip Enforcer
Esoteric Alteration Gem of Ease Gem of Efficacious Toxin Gogok of Swiftness Iceblink
Invigorating Gemstone Legacy of Dreams Mirinae, Teardrop of the Starweaver Molten Wildebeest’s Gizzard Moratorium
Mutilation Guard Pain Enhancer Red Soul Shard Simplicity’s Strength Taeguk
Wreath of Lightning Zei’s Stone of Vengeance Bane of the Powerful

Game Information

  • Mode: Multiplayer video game
  • Writer: Chris Metzen
  • Composer: Russell Brower
  • Platforms: Nintendo Switch, PlayStation 4, Xbox One, PlayStation 3,
  • Official Site: Website



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